cAMP: a multifaceted modulator of immune synapse assembly and T cell activation
نویسندگان
چکیده
منابع مشابه
A review of Biology and clinical use of Mesenchymal stem cell: an immune -modulator progenitor cell
Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...
متن کاملAssembly and function of the natural killer cell immune synapse.
During the natural killer (NK) cell immune response, cytoskeletal components, adhesion and signaling molecules and ligand-specific receptors are involved in the formation of the natural killer cell immune synapse (NK-IS), a highly organized supramolecular structure assembled at the interface of the interacting cells that regulates the NK cell activation and decides the target cell fate. In this...
متن کاملBiophysical Aspects of T Lymphocyte Activation at the Immune Synapse
T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen-presenting cells (APCs). T lymphocyte activation also involves engagement of costimulatory receptors and adhesion molecules recognizing ligands ...
متن کاملThe T cell IFT20 interactome reveals new players in immune synapse assembly.
Sustained signalling at the immune synapse (IS) requires the synaptic delivery of recycling endosome-associated T cell antigen receptors (TCRs). IFT20, a component of the intraflagellar transport system, controls TCR recycling to the IS as a complex with IFT57 and IFT88. Here, we used quantitative mass spectrometry to identify additional interaction partners of IFT20 in Jurkat T cells. In addit...
متن کاملIFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Biogenesis of the immune synapse at the interface between antigen-presenting cells and T cells assembles and organizes a large number of membrane proteins required for effective signaling through the T-cell receptor. We showed previously that the intraflagellar transport protein 20 (IFT20), a component of the intraflagellar transport system, controls polarized traffic during immune synapse asse...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2017
ISSN: 0741-5400,1938-3673
DOI: 10.1189/jlb.2ru1116-474r